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I/R damages affected tissue through numerous pathological processes, such as inflammation, oxidative stress, disturbance of cellular signalling pathways, and cell apoptosis and necrosis 2

Science 273 , 788791 (1996)

Kulmala RV, Lehtonen TA, Lindholm TS et al: Permanent open shunt as a reason for impotence or reduced potency after surgical treatment of priapism in 26 patients

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Blood, 126 (23)

It has the capacity to oxidize cellular macromolecules, including lipids and proteins, which can result in cell death