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Although momentous for tissue repair and regeneration, DAMPs could bring about sterile inflammation (49)

Advanced Biomedical Research

Polonikov, Kursk State Medical University, Russia Chao Ling, Peking Union Medical College Hospital (CAMS), China Updates Copyright 2023 Xu, Yu, Zhou, Wu, Deng, Wu, Wang, Gao, Nie, Zhou, Sun and Huang

It is not quite clear what causes these nerves to become overactive

It improved colonic inflammation, suppressed the NOD-like receptor protein 3 (NLRP3) inflammasome, and increased short-chain fatty acid-producing bacterial genera, which collectively contributed to mucosal healing and immune regulation

Also, chronic hyperglycemia increased inflammation and oxidative stress that play an important central role in the pathogenesis of diabetes complications [8]