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38,5658 However, instead of enhancing the injury mechanism as intended, this modulation changed the injury process altogether from a protein adduct-driven signaling process to one dominated by LPO

Hypocortisolism Under acute conditions the proinflammatory cytokines IFN-, TNF, IL-1, and IL-6 stimulate the hypothalamicpituitaryadrenal (HPA) axis by stimulating ACTH secretion [54, 236]

When large amounts of iron are present in the body, ROS are generated, causing lipid peroxidation, damaging the lipid membranes, and causing cell death [105]

Since inflammation of the large intestine affects brain function through braingut interaction, patients with colitis are at a high risk of developing psychiatric disorders, such as depression and anxiety, during the exacerbation period 43,44

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Kasri et al., 2009