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Glycoursodeoxycholic acid (GUDCA) is BA metabolites, can significantly reduce ER stress markers such as C/EBP Homologous Protein (CHOP), phosphorylated inositol-requiring enzyme 1 (p-IRE1), phosphorylated p38 MAPK (p-p38), and phosphorylated c-Jun N-terminal kinase (p-JNK)

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Disruption of the GH/JAK2/STAT5 signaling pathway, a result of inhibited growth hormone (GH) secretion (brought on by obesity, inflammation, and excessive glucose), results in increased lipid accumulation in the liver, further leading to MAFLD and subsequently HCC (108)

Method 3: Using numerical methods for interpolating digitized capacity graphs

Most naturally occurring unsaturated fatty acids in the body have double bonds with cis configuration