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In support of this idea, when holoTC concentrations were subtracted from total vitamin B-12 concentrations, the remaining vitamin B-12, represented by the holohaptocorrin (holoHC) fraction of serum vitamin B-12, was unaffected by the concentration of plasma folate (Figure 8B)

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MOTS-c has a half-life of 46 hours and works best when administered during metabolic windows where AMPK activation is already primedfasted states, pre-training, or during caloric deficit periods

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