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Therefore, exogenous expression in aged astrocytes of a cytoplasmically targeted PC gene could possibly decrease cellular senescence and inflammation from the senescence-associated secretory phenotype (SASP) to delay brain aging
Teskey, G., et al., Glutathione as a Marker for Human Disease

The pharmacokinetic rationale is questionable given tirzepatide 5-day half-life

M.RegaladoA.AgeorgesA.BurlaB

Gut 43, 592594