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In an effort to maintain good mAb quality during the cultures, HCPs accumulated extracellularly in batch and fed-batch cultures of a mAb-producing rCHO cell line were identified and quantified by nanoflow liquid chromatography-tandem mass spectrometry, followed by their gene ontology and functional analysis

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Cuproptosis is characterized by mitochondrial impairment resulting from copper interacting with lipoylated components of the tricarboxylic acid (TCA) cycle, leading to proteotoxic stress and targeted cell death

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The cumulative urinary excretion of the parent drug amounted to only 3.01%