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The mice were once intravenously injected with cisplatin in a single half-lethal dose of 15 mg/kg (this dose caused a death of 50% of the animals)

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Flavones and their synthetic derivatives demonstrate various biological activities, including antioxidant, antitumor, antiallergic, anti-inflammatory, cardioprotective, and antimicrobial effects (Sing et al

these cells maintain HER2 + status in vivo, and show a high tendency toward spontaneous and experimental brain metastasis in a mouse model

doi: 10.3389/fncel.2021.692762 Received 09 April 2021 Accepted 20 May 2021 Published 15 June 2021 Volume 15 - 2021 Edited by David Z

By employing a conditional gene expression strategy on an ApoE knockout background to eliminate interference from endogenous central ApoE, the study demonstrated that peripheral expression of ApoE4 alone is sufficient to induce memory impairment, BBB leakage, and perivascular gliosis, with a severity comparable to that observed in systemic ApoE4 expression models [88]