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Other metabolic derangements associated with ethanol metabolism result from the fact that ADH and ALDH metabolize not only ethanol but also other compounds

"Genetics are often the primary driver of premature graying but environment and lifestyle factors also play a role and can accelerate it." While optimizing glutathione and antioxidant levels can help, Lee said it won't compensate for systemic poor health including smoking, high alcohol intake and processed food-heavy diets

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Intensive studies are still required to unravel the crosstalk between different NRF2-regulated metabolic pathways and diseases and enable the development of a better strategy for combating human diseases

Guidance for industry: evidence-based review system for the scientific evaluation of health claims - final
