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[DOI] [PMC free article] [PubMed] [Google Scholar] 211.o-Rycharska E, Kieraszewicz Z, Czerwionka-Szaflarska M

Despite that cancer cell lines have been widely used in studying drug response, their genomic alteration (duplicated, deleted, fused, etc.) and the nature of heterogeneity have prevented them from being employed in the study of inheritable SNP-dependent responses to natural ligands and drugs such as those used in this study

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Pharmacological determinantsdose and durationgovern target engagement

This trend is also observed in the maximum peak area, arising to 15,727 at 100% concentration (2.3750 g/mL), 20,243 at 120% concentration (2.8500 g/mL and highest at 26,998 at 160% concentration (3.8000 g/mL)
