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Mol Cell (2009) 36(1):13140

In vivo experiments showed the peptide rapidly restoring blood flow through collateral vessel activation in models of venous occlusion, an effect closely linked to the NO system and reduction of free radical formation

doi: 10.1016/j.neubiorev.2021.07.023

Consistent with a tandem duplication event, the two human genes are closely linked, separated by 40 kb, exhibiting similar intron/exon structure, and 90 and 95% identity in the coding and non-coding sequences, respectively (59, 70)

GST class-mu 3

This study confirmed that macrophages secreted NO to adjacent epithelial cells, preventing phospholipid peroxidation in epithelial cells, thereby inhibiting ferroptosis, while NO expression did not affect intracellular GPX4 levels