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Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells

These pathological pathways are probably mediated, at least in part, through NLRP3 inflammasome stimulation and mitochondrial disruption

doi:10.1016/j.cmet.2019.08.001

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Combination therapy erases this gap while adding complexity and cost

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