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Acetyl-CoA is then converted into citrate by the mitochondrial citric acid cycle, which is subsequently transported to cytosol and converted into fatty acid by the actions of lipogenic enzymes such as ATP-citrate lyase (ACLY), acetyl-CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase-1 (SCD1), and fatty acid synthase (FASN) (41, 465)