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Patients with Lyme usually find that fatigue and pain improve with increased exercise

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[DOI] [PubMed] [Google Scholar] 88.Friedlander AL, Butterfield E, Moynihan S, Grillo J, Pollack M, Holloway L, Friedman L, Yesavage J, Matthias DF, Lee S, Marcus R, Hoffman AR

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At the onset of motor symptoms, R6/1 mice displayed reduced striatal expression of PAC 1 R levels, which IN-PACAP restored, while it additionally restored levels of CREB-binding protein and BDNF [203]