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In normoxia (normal oxygen levels), prolyl hydroxylase hydroxylates HIF-1 at two proline residues (Pro 402 and Pro 564)
For the normal masking effects of light, such as inducing activity by light and inhibition by darkness
USA 107 , 35823587 (2010)
However, elevated H 2 O 2 is associated with oxidative stress, causing damage to cell membranes, proteins, and DNA, thereby linking it to pathologies including cancer and neurodegenerative diseases [47]
Nunn, P
