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Importantly, the cannabis-responsive biomarkers quantified the impact of MC treatment on the children with ASD, shedding light on the underlying pathophysiology of ASD and indicating a possible mechanism of action (MOA) of cannabinoids

32 After 2 months of treatment, the group of patients treated with a combination of oral ALA 600 mg/d and gabapentin 300 mg/d reported the greatest improvement in symptoms, with 70% of these patient reporting a reduction in pain

Reduced vasotension and relaxed capillary sphincters allow considerably elevated local blood flow into the capillary bed thereby providing an enhanced exchange of nutrients and metabolic products

National Guideline C
