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I havent heard of many people having this side effect, and I even asked my PCP

10.1007/s11373-005-9055-5 5 AnJ.ChengL.YangL.SongN.ZhangJ.MaK.et al (2021)

Unlike other organelles such as mitochondria, where an abundance of reduced glutathione (GSH) preserves a reductive environment, the ER requires an oxidizing milieu to facilitate the formation of disulfide bonds critical for protein structural integrity

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Opening at 2 mg weekly rather than 4 mg markedly softens early GI effects, and any higher weekly dose simply calls for more than one vial or a split across two sites

From a clinical standpoint, glutathione is considered safe and beneficial when administered correctly and under professional supervision