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These were ethyl cyclohexane (2.15 %), ethylbenzene (1.19 %), p-xylene (5.25 %), o-xylene (1.34 %), nonane (1.39 %), mesitylene (0.613 %), decane (4.507 %), undecane (0.739 %), dodecane (0.468 %), tridecane (0.418 %), n-hexadecanoic acid (0.723 %), oleic acid (1.16 %), bis(2-ethylhexyl) phthalate (80.7 %), and cholesterol (1.542 %)

Currently, EPI-743 is gaining relevance for the treatment of epilepsy [164,166] and Friedreich ataxia, being responsible for a significant improvement in neurological function and an arrest of disease progression [167,181,182]

Therefore, chronic stress-induced dysregulation of the HPA axis, potentially mediated by imbalances in gut microbiota, might be a crucial link between dysbiosis and the progression of AD (Figure 1)

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doi: 10.1098/rsob.150171 35 ChenXSchneewindOMissiakasD