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Transfection of the common G2019S LRRK2 mutation into SH-SY5Y cells was reported to increase autophagy in both neuritic and somatic compartments [70]
Previously, there was this theory that lipophilic statins crossed the blood brain barrier more and had more neurocognitive effects, this is no longer thought to be true
Colivicchi, F., Bassi, A., Santini, M
10.1016/j.jconrel.2023.04.027 253 ZhaoL
The key factor is a high initial concentration in relation to the C 50
