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Retrieved February 13, 2018
Molecules 24
[DOI] [PubMed] [Google Scholar] Patel R
Nutrition, Well-Being and Health
NO is synthesized by eNOS in endothelial cells and diffuses to vascular smooth muscle, where it activates the cytosolic form of guanylate cyclase (also known as guanylyl cyclase) to form cyclic guanosine monophosphate (cGMP)
This leads to the neutralization of their positive electrostatic charge, which may influence protein interactions with substrates, cofactors, and other macromolecules 116,117,118
