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It is not common, but it is the primary reason we adjust or discontinue GHK-Cu protocols when side effects arise

In our previous study we described that the A-GSH dual-targeting elevated the BBB penetration of 3-PLGs [24]

human evidence is largely topical and injectable use is unproven
72%, respectively) [31]
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Future Phase III trials (e.g., ongoing photoaging studies) may further clarify its utility [12]

By carefully optimizing lipid composition, loading method, and processing conditions, researchers can maximize encapsulation efficiency while preserving biological function