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ISBN:1-56670-670-2 Montella M, Franceschi S, Geddes da Filicaia M, De Macro M, Amiani S, Balzi D, Delfino M, Lannuzzo M, Buonanno M, Satriano RA (1997) Epidiemologia e Prevenzione 21:114117 Morais S, Garcia F, Pereira ML (2012) Chapter 10: Heavy metals and human health

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While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

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