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Astrocyte senescence promotes glutamate toxicity in cortical neurons

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On the cancer front, a dual inhibitor of NQO1 and glutathione transferases, called MNPC (5-methyl-N-(5-nitro-thiazol-2-yl)-3-phenylisoxazole-4-carboxamide), has been synthesized and characterized [110]

In addition, peripheral BDNF is reduced in aging, which is commonly associated with AD risk (Molinari et al., 2020)