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and inflammatory cytokines such as macrophage inflammatory protein 1 (MIP-1), tumor necrosis factor (TNF-), leukemia inhibitory factor (LIF), hepatocyte growth factor (HGF), IL-1, IL-3, IL-6, IL-8, IL-10, and IL-17 (Table 1) (108, 293, 393, 429, 476, 496)

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Amino acids and biogenic amines were analyzed by liquid chromatography (LC) coupled to tandem mass spectrometry, while other metabolites were analyzed using flow-injection analysis (FIA) coupled to tandem mass spectrometry

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11,25 Across the studies that reported serious/severe AEs, serious events were rare (2 in the treatment arm and 1 in the control) and, when adjudicated, not attributed to ALC