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Lipid imbalance is particularly important in the CNS as the brain is approximately 60% lipid (dry weight) and has a unique composition, compared to other tissues, that is highly enriched in critical omega-3 and omega-6 fatty acids 2, 3 As such, lipid dysregulation contributes substantially to neurologic dysfunction 4, 5 as they are necessary for maintaining cellular homeostasis, proper structure, propagating action potentials, use as signaling molecules, and as a source of energy 57

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Hua S, Sun Z: Support vector machine approach for protein subcellular localization prediction