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10.1097/00075197-200011000-00006 Curr

GSH is the most abundant endogenous antioxidant in the brain and plays an important role in counteracting oxidative stress (Lu, 2013

Furthermore, it was found that the general control of amino acid synthesis 5-like 1 (GCN5L1) negatively regulates both mitochondrial biogenesis and degradation pathways through acting on both PGC1a and TFEB in mouse embryonic fibroblasts (Scott et al., 2014)

Concluding remarks The levels and compartmentalization of NAD + dictate energy state that impinges on normal physiological and biological responses, as indicated by the regulatory role of NAD + in proper redox homeostasis, genomic stability, gene expression, circadian clock, inflammation, metabolism, cellular bioenergetics, mitochondrial homeostasis and adaptive stress responses