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Most supplements have a modest impact on weight loss and these are most efficient when combined with regular exercise and a healthy diet

The reason is that larger bodies may require more of the compound to break down fat efficiently

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Aug 2010;14(4):467-473

The authors explained this fact by a compensatory mechanism to counter the detrimental effects of oxidative stress within the brain

Mol Psychiatry 27:50495061 [DOI] [PMC free article] [PubMed] [Google Scholar] 14.Bot M, Milaneschi Y, Al-Shehri T, Amin N, Garmaeva S, Onderwater GLJ, Pool R, Thesing CS, Vijfhuizen LS, Vogelzangs N, Arts ICW, Demirkan A, van Duijn C, van Greevenbroek M, van der Kallen CJH, Kohler S, Ligthart L, van den Maagdenberg A, Mook-Kanamori DO, de Mutsert R, Tiemeier H, Schram MT, Stehouwer CDA, Terwindt GM, Willems van Dijk K, Fu J, Zhernakova A, Beekman M, Slagboom PE, Boomsma DI, Penninx B, Consortium B-NM (2020) Metabolomics profile in depression: a pooled analysis of 230 metabolic markers in 5283 cases with depression and 10,145 controls