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Figure 5 summarizes the observations of the toxicity papers reviewed with the most commonly perturbed metabolites and metabolic pathways

10.3390/ijerph18136723 319 ZhangT.TianG.WangX

Experimental evidence of -3 polyunsaturated fatty acid modulation of inflammatory cytokines and bioactive lipid mediators: their potential role in inflammatory, neurodegenerative, and neoplastic diseases

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The 7% body weight reduction observed in mouse models may not translate proportionally to human weight loss it could be more, less, or require entirely different dosing and duration