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Ames BN, Cathcart R, Schwiers E, Hochstein P

Additionally, NAC also helps regulate glutamate homeostasis, reduce cytokines (such as IL-6, IL-1, and TNF-), and enhance mitochondrial function [110, 111]

TNF- has been shown to cause up regulation of expression of Manganese (Mn) superoxide dismutase in the endometrium in vitro [82]
doi:10.1210/jc.2015-3473

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Overdose No cases of overdosage have been reported in the literature