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The anorexia associated with cancer cachexia is likely caused by the activity of pro-inflammatory cytokines, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), interleukin-6 (IL-6) and growth differentiation factor 15, that are produced either by the tumor or by the host in response to the tumor, which interfere with appetite signals within the anterior hypothalamus (8, 9)

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Ogden CL, Fryar CD, Martin CB, Freedman DS, Carroll MD, Gu Q, Hales CM (2020) Trends in obesity prevalence by race and hispanic Origin19992000 to 20172018

Once inside mitochondriathe tiny powerhouse organelles that generate energy in every cellfats are broken down to fuel energy production

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