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It is the key regulator of insulin-like growth factor 1 (IGF1), which is secreted from target tissues, particularly the liver

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Lactate concentrations in incisions indicate ischemic-like conditions may contribute to postoperative pain

Malic enzymes ME participate in reactions that link the components of catabolic metabolism in glycolysis and the Krebs cycle via the oxidative decarboxylation of malate to pyruvate, thereby inducing the anabolic metabolism with concomitant NADPH production

Sci Rep 13 , 9813 (2023)