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Finally, we discuss emerging strategies to interrogate and modulate this circuit using integrated omics, CRISPR-based screening, and pharmacological approaches, emphasizing the need for context-aware and temporally controlled metabolic interventions to enhance T cellbased immunotherapies in solid tumors

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A prominent disparity between pediatric and adult cancers lies in the considerably lower mutational burden observed in pediatric malignancies [447]

In addition, 5hmC suppression induced by L2HG treatment is partially restored by DMF treatment (Fig

Increased thioredoxin-1 production in human naturally occurring regulatory T cells confers enhanced tolerance to oxidative stress

Association of Tumor Necrosis Factor- (TNF-) Gene Promoter Polymorphisms with Aggressive and Chronic Periodontitis in the Eastern Indian Population. Bioscience Reports, vol