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In fact, reports of bacterial endotoxin in the pelvic cavity and menstrual blood of people with endometriosis 37 have led to a bacterial contamination hypothesis suggesting endotoxin/bacteria in the menstrual effluent contributes to pelvic inflammation, growth, and progression of endometriotic lesions (reviewed in 38,39 )

This is a peptide substance that regulates and promotes growth

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It was first isolated in 1974 from the cerebral venous blood of rabbits in a sleep state by Monnier and colleagues, making it one of the earlier identified endogenous neuropeptides associated with sleep-wake cycle regulation research