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Recent studies have assessed the use of stem cells as a promising and advanced therapeutic approach for acute and chronic injuries to overcome the limited number of donors and endstage organ failure (110)

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Subchronic toxicity study of gallic acid by oral administration in F344 rats

All three mRNA splice variants encode C-terminal extensions termed E-domains to denote their positions relative to the BCAD domains of mature IGF-I: mRNAs containing exon 4 spliced to exon 6 are designated as IGF-IEa, mRNAs containing exon 5 spliced to exon 4 have been designated as IGF-IEb, whereas those containing exon 4 spliced to exon 5 and exon 6 are designated IGF-IEc in humans (Fig 1)[2]

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In the opinion of the authors additional pathogenetic mechanisms besides polyol-pathway activation or, alternatively, insufficient ARI dosage could be responsible for the incomplete prevention of neuropathy [23]