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Drug Des Devel Ther 12:41174127

The oxidized product Di-NAC was quantified with freshly prepared Di-NAC standard the results are summarized in Table 6

S3), indicating that the combination regimen caused no overt systemic toxicity

The trial achieved its primary outcome, as BBM-P002 demonstrated a favorable safety and tolerability profile within 12 months post-treatment

Overexpression experiments show increased GSH levels and greater resistance to oxidative stress, while knockdown or disease-associated mutations make cells more susceptible to redox imbalance [12,71,72]

Nrf2-mediated protection against 6-hydroxydopamine