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Insufficient drug delivery into the brain leads to low therapeutic efficacy as well as aggravated side effects due to the accumulation in other organs and tissues

The present study shows that the pharmacokinetic characteristics of NAC after oral administration of tablets are similar in healthy Chinese and Caucasian individuals after single and repeated administration

doi: 10.1093/jnci/djt315 241

Mistake 3: Sloppy Sterile Technique

Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition

This recruitment leads to a conversion of its pro-apoptosis activity into antiferrotic effects (Bersuker et al