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In zinc-deficient females, the quality of the eggs may be affected, reducing the likelihood of successful fertilization

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De novo synthesis of serine from the glycolytic intermediate 3-phosphoglycerate (3-PG) occurs through a pathway consisting of three sequential steps: phosphoglycerate dehydrogenase (PHGDH) oxidizes 3-PG to 3-phosphohydroxypyruvate (pPYR) using an NAD + cofactor, phosphoserine aminotransferase (PSAT) transaminates pPYR to phosphoserine (pSER) using glutamate as the nitrogen donor, and finally phosphoserine phosphatase (PSPH) dephosphorylates pSER to produce serine [68]

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However, with the advent of the modern era, a paradigm shift occurred as scientists increasingly relied on synthetic and semi-synthetic antibiotics for combating microbial infections (Abdallah, 2011)