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Generally acting as a tumor suppressor, ChaC2 decreases GSH levels in tumor cells, instigates mitochondrial apoptosis and autophagy via UPR and hinders tumor cell proliferation and migration in vitro and in vivo (79)

This mechanism likely helps cells cope with metabolic and oxidative stress

The glucosylated form of reduced lawsone, 1,2,4-trihydroxynaphthalene-1- O -glucoside (Figure 1b), has been reported in Impatiens glandulifera (Himalayan balsam), thus pointing to the presence of an oxidoreductase and a glycosyltransferase analogous to those involved in metabolizing juglone

ChemBioChem 13 , 11161120 (2012)

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