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Vitamin B12 was initially discovered more than 70 years ago during a search for the "anti- pernicious anemia factor" found in liver extracts used to treat pernicious anemia (1,2)

The clinical spectrum of disease caused by these virus ranges from asymptomatic infection to severe disease, characterized by pneumonia, dyspnea, and febrile illness, progressing in severe cases into acute respiratory distress, sepsis, and death from multiple organ failure [6]

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Some drugs, including proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs) are acid-inhibiting, impairing the release of dietary B12 from food proteins, thus producing risk of B12 deficiency (Lam et al., 2013)

On August 1, 1885, The New York Times stated that Perley was presented with a gold watch by members of the Reno Post in recognition of his years of service as its commander

272,275 see Figure 23