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Complementary thioredoxin mimetics exemplified by TXM-CB3 indirectly support GRX systems through the replenishment of reducing equivalents, attenuating mitochondrial SSG overload in neurodegenerative contexts (78)

doi: 10.1667/rr3236 110 ShaoCFurusawaYKobayashiYFunayamaTWadaS

1997;273(1 Pt 1):G7-17

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing sp1 glycosylation
Cotargeting BCL-2 and PI3K induces BAX-dependent mitochondrial apoptosis in AML cells

However, it also produces some direct and indirect side effects
