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The widespread G-protein bias with minimal -arrestin-2 recruitment offers a plausible mechanistic explanation for kratoms atypical safety profile relative to classical opioids (Hemby et al., 2018

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At higher doses, some concern exists about pro-inflammatory effects: LL-37 can activate NF-kB pathways, potentially worsening certain inflammatory conditions

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Studies suggest that Epithalons ability to regulate telomerase activity also indirectly benefits mitochondria, as shorter telomeres are associated with mitochondrial dysfunction