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Primary Metabolic Pathways Beta-3-Adrenergic Receptor Modulation Research in obese mice demonstrated that AOD-9604 increases expression of beta-3-adrenergic receptor RNA in adipose tissue, upregulating levels from those seen in obese animals to levels comparable with lean controls

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This compound is examined in controlled in vitro research settings, including cellular models and biochemical pathway analysis

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NNMT inhibitors are selective and do not impact related methyltransferases or enzymes in the NAD + salvage pathway The selectivity of NNMT inhibitors was confirmed by testing against a panel of structurally similar methyltransferases and two enzymes in the NAD + salvage pathway (NAMPT and SIRT1

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