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In the APAP hepatotoxicity-mediated immune response, KCs form the first line of defense by recognizing necrotic hepatocytes caused by drug injury through DAMPs, and KCs, upon activation release of cytokines such as IL-6, IFN, TNF and chemokines to regulate hepatocyte function

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[DOI] [PMC free article] [PubMed] [Google Scholar] 177.Warnke M.M., Wanigasekara E., Singhal S.S., Singhal J., Awasthi S., Armstrong D.W