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In conclusion, treatment with once-weekly subcutaneous semaglutide in conjunction with behavioral intervention in adults with overweight (with at least one weight-related comorbidity) or obesity (without diabetes) was associated with clinically impactful and sustained weight loss of 15.2% at week 104, along with improvements in weight-related cardiometabolic risk factors

Additionally, berberine, an alkaloid found in several plants including goldenseal and barberry, further supports SIRT1 activation through its ability to induce NAD + biosynthetic pathways and improve metabolic health 180

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