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doi: 10.3389/fchem.2023.1249472 Received 28 June 2023 Accepted 04 September 2023 Published 15 September 2023 Volume 11 - 2023 Edited by Graeme Stasiuk, Kings College London, United Kingdom Reviewed by Lakshmi Narayanan Mosur Saravana Murthy, Intel, United States Manuel Baobre-Lpez, International Iberian Nanotechnology Laboratory (INL), Portugal Updates Copyright 2023 Liu, Guo, Li, Jia, Xie, Wang, Tian, Li and Hao

Consequently, iron deficiency or impaired metabolism can lead to damage to nigrostriatal neurons and disruption of the dopamine system, which is a primary pathobiological factor in restless legs syndrome (RLS) [73, 74]