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Association of cortical macrostructural and microstructural changes with cognitive performance and gene expression in subcortical ischemic vascular disease patients with cognitive impairment

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As the barrier of CNS, the low permeability of BBB separates neural tissue from circulating blood, and the infiltration of leukocytes (such as neutrophils, lymphocytes) in CNS is much less than that in peripheral tissues, CNS was often considered as an immune privileged site in the past (Liebner et al., 2018)