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doi: 10.1101/gad.2016111 245 YangARajeshkumarNVWangXYabuuchiSAlexanderBMChuGCet al

van Lennep J (Hans)PA, Trossl F, Perez RSGM, Otten RHJ, van Middendorp H, Evers AWM, et al

Because rheumatoid arthritis involves immune system activity, anyone considering peptide therapy should work closely with a qualified medical professional

Verify solubility and pH compatibility empirically for your assay system

It may stimulate increases in blood pressure, serum triglycerides, and fasting plasma glucose, so those with metabolic syndrome should beware of it without proper supervision

This stability profile distinguishes it from many peptide-based research compounds and has contributed to interest in its biochemical persistence, signaling activity, and pathway-specific effects in mechanistic investigations