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NAD+ is essential for the electron transport chain in mitochondria, where the majority of cellular ATP is produced

Most people tolerate them well, with minimal side effects

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Indeed, B12 and folate interact in the metabolism of methyl group in the transform from 5-MTHF to homocysteine, and this reaction is mediated by B12 dependent methltransferase, which results in the formation of methionine

Br Med J 1963;2:225-7

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