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This was evidenced by in vivo studies, which revealed a markedly reduced expression of PGC-1 and its target genes in the striatum and muscle of HD mice ( A number of in vivo studies have demonstrated that mHtt is involved in the process of mitophagy or regulates intermediately important aspects in animal models of HD

According to the statistics from World Health Organization, RA is one of the most challenging diseases for both the physicians and patients ( Figure 1 )

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A systematic review of brain injury epidemiology in Europe