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A., Niehaus M., Steven R

[39] Maleki V, Jafari-Vayghan H, Kashani A, et al

Christopher G, Sutherland D, Smith A

12 This review will therefore provide the reader with a comprehensive understanding of the clinical presentation, pathogenesis, and genetics of MCADD before discussing modern developments in the diagnosis and treatment that may provide improved patient outcomes

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First described in the early 19th century, the pigment was initially thought to be melanin, but it was later found to be lipofuscin deposited in macrophages within the lamina propria as a result of apoptosis